Research Article The IL18 rs1946518 and PTPN22 rs2476601 polymorphisms are not associated with adult- and childhood-onset type 1 diabetes mellitus
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چکیده
منابع مشابه
Tonsillectomy and adenoidectomy are not associated with an altered risk of childhood-onset type 1 diabetes.
T ype 1 diabetes results from the autoimmune destruction of the pancreatic -cells. As various studies have shown that tonsillectomy and adenoidectomy, particularly in childhood, impact the function of the immune system (1), it is possible that these procedures could increase a child’s risk of type 1 diabetes. Conversely, the hygiene hypothesis (2) suggests that frequent exposure to infections i...
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چکیده ندارد.
Environmental Factors before the Onset of Type 1 Diabetes Mellitus: A Case-Control Study
Objective: The role of environmental factors in the development of type1 diabetes mellitus (T1D) is inconclusive. This study aimed to investigate the associations between selected environmental factors and T1D. Materials and Methods: This group matched case-control study included diabetic and healthy subjects younger than 19 years old in 2017. Cases were diabetic subjects diagnosed before the ...
متن کاملVitamin D gene polymorphisms are associated with type 1 diabetes mellitus in Korean youth
Vitamin D deficiency is reported in patients with type 1 diabetes mellitus (T1DM). Allelic variations in the gene associated with vitamin D metabolism were reported to play a role in glucose metabolism. CYP2R1 and CYP27B1 gene polymorphisms were investigated as a candidate gene for T1DM in Korean youth. We measured serum level of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in 217 subjects a...
متن کاملEnvironmental factors associated with childhood-onset type 1 diabetes mellitus: an exploration of the hygiene and overload hypotheses.
OBJECTIVE To assess the relationship between selected maternal and infant characteristics and risk of type 1 diabetes mellitus, specifically characteristics identified from birth records that may pertain to the hygiene or overload hypotheses. DESIGN Population-based case-control study. SETTING Washington State from 1987 to 2005. PARTICIPANTS All children younger than 19 years hospitalized...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2020
ISSN: 1676-5680
DOI: 10.4238/gmr18686